The relationship between aging and carcinogenesis is being explored by transforming cells derived from young and old animals with various oncogenes. The rates of immortalization and transformation will be examined to determine if older cells respond differently from younger cells. Cells from several species will be examined, cells from different tissues in the same animal will be compared, and different combinations of oncogenes will be used.
| Sharov, Alexei A (2009) Role of Utility and Inference in the Evolution of Functional Information. Biosemiotics 2:101-115 |
| Sharov, Alexei A; Masui, Shinji; Sharova, Lioudmila V et al. (2008) Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics 9:269 |
