The goals of these studies are: (1) to identify and localize the transcriptional regulatory sequences within the long terminal repeats (LTRs) of different gibbon ape leukemia virus (GALV) strains; (2) to compare the relative transcriptional ability of the different strains and examine their tissue specificity of expression; and (3) having identified the regulatory sequences, to isolate and purify the trans-acting cellular factors which interact with these sequences to enhance the transcriptional activity.
| Carter, Mark G; Stagg, Carole A; Falco, Geppino et al. (2008) An in situ hybridization-based screen for heterogeneously expressed genes in mouse ES cells. Gene Expr Patterns 8:181-98 |
| Sharova, Lioudmila V; Sharov, Alexei A; Piao, Yulan et al. (2007) Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. Dev Biol 307:446-59 |
| Falco, Geppino; Lee, Sung-Lim; Stanghellini, Ilaria et al. (2007) Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells. Dev Biol 307:539-50 |
