C3H/HeN (responsive to Lipid-A and C3H/HeJ (not responsive to Lipid A) were primed with sheep erythrocytes so as to generate significant immunological memory. When these mice were treated subsequently with bacterial lipopolysaccharide (LPS), significant polyclonal activation of memory cells was noted only in C3H/HeN mice. This suggest that the Lipid A moiety of the LPS molecule plays an important role in the activation of memory B cells.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000143-19
Application #
3821966
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code