Abstract

Because the adverse reactions associated with treatment of onchocerciasis, loiasis, and lymphatic filariasis can be severe, systemic, and debilitating the mediators of this posttreatment reaction have been identified and quantified. In the acute phase (first 48 hours) an intracellular Wolbachia endosymbiont appears in the bloostream and is correlated with the presence of the inflmmatory mediators of the posttreatment adverse reactions. Later, the eosinophil plays a major role as do the chemokines associated with eosinophil trafficking.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000439-19
Application #
6808178
Study Section
(HIS)
Project Start
Project End
Budget Start
Budget End
Support Year
19
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Cirino, Christopher M; Leitman, Susan F; Williams, Esther et al. (2008) Transfusion-associated babesiosis with an atypical time course after nonmyeloablative transplantation for sickle cell disease. Ann Intern Med 148:794-5
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Kim, Yae-Jean; Dale, Janet K; Noel, Pierre et al. (2007) Eosinophilia is associated with a higher mortality rate among patients with autoimmune lymphoproliferative syndrome. Am J Hematol 82:615-24
Klion, Amy D; Robyn, Jamie; Maric, Irina et al. (2007) Relapse following discontinuation of imatinib mesylate therapy for FIP1L1/PDGFRA-positive chronic eosinophilic leukemia: implications for optimal dosing. Blood 110:3552-6
Maric, Irina; Robyn, Jamie; Metcalfe, Dean D et al. (2007) KIT D816V-associated systemic mastocytosis with eosinophilia and FIP1L1/PDGFRA-associated chronic eosinophilic leukemia are distinct entities. J Allergy Clin Immunol 120:680-7
Lipner, Ettie M; Law, Melissa A; Barnett, Elizabeth et al. (2007) Filariasis in Travelers Presenting to the GeoSentinel Surveillance Network. PLoS Negl Trop Dis 1:e88
Dicko, Alassane; Sagara, Issaka; Diemert, David et al. (2007) Year-to-year variation in the age-specific incidence of clinical malaria in two potential vaccine testing sites in Mali with different levels of malaria transmission intensity. Am J Trop Med Hyg 77:1028-33
Klion, Amy D (2007) Approach to the therapy of hypereosinophilic syndromes. Immunol Allergy Clin North Am 27:551-60
Nutman, Thomas B (2007) Evaluation and differential diagnosis of marked, persistent eosinophilia. Immunol Allergy Clin North Am 27:529-49
Lipner, Ettie M; Gopi, P G; Subramani, R et al. (2006) Coincident filarial, intestinal helminth, and mycobacterial infection: helminths fail to influence tuberculin reactivity, but BCG influences hookworm prevalence. Am J Trop Med Hyg 74:841-7

Showing the most recent 10 out of 40 publications