CD8+ T cells (TCD8+ ) play an important role in controlling virus infections. TCD8+ recognize peptides of 8 to 10 residues derived from viral proteins located in the cytosol of virus infected cells. These peptides are recognized in a complex with class I molecules encoded by the major histocompatibility complex (MHC). The MHC also encodes two molecules, termed TAP1 and TAP2, that combine to create a complex (TAP) that delivers peptides from the cytosol into the endoplasmic reticulum (ER) where they are assembled with class I molecules. In the absence of TAP, cells have a slight, but still significant, capacity to deliver cytosolic peptides to the ER. In this project we investigate whether this is due to the multi drug resistance protein (MDR), a transporter related to TAP that plays an important role in the resistance of tumors to chemotherapy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000652-07
Application #
6099006
Study Section
Special Emphasis Panel (LVD)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1998
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code