We have demonstrated that mouse FcgammaRII and FcgammaRIII are not isotype specific and are capable of binding IgE immune-complexes. Furthermore, the binding of IgE immune-complexes to these receptors induces cell activation. We also have generated transfectants expressing human FcgammaRII and FcgammaRIII and we are at present studying whether our findings in the mouse system will be relevant in the human system.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000663-01
Application #
3790896
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
City
State
Country
United States
Zip Code