Seizures are the most common clinical manifestation of cerebral cysticercosis and occur in the presence of viable, dying, and calcified or non-calcified dead cysts. How calcified cysts provoke seizures is not known but recent observations demonstrated edema around some calcified lesions at the time of seizure activity and disappearance during periods when seizures were not occurring. Edema associated with foci in idiopathic epilepsy is highly unusual so that this observation suggests that the mechanism(s) associated with calcified cysts is unique. Documenting and understanding this phenomenon is important for a number of reasons. First, although by definition these lesions are inactive, e.g., not living larvae and do not require anti-parasitic treatment, they are frequently mistaken for active lesions and patients undergo unnecessary treatment. Second, a likely reason for perilesional edema is intermittent antigen release and subsequent host immune response resulting in inflammation and edema. If proven, then the treatment for this would not only involve suppression of seizure activity with anti- seizure medication, but also the use of anti-inflammatory medications such as corticosteroids. A study was initiated in Peru to determine 1) the frequency of perilesional edema around calcifications 2) the nature and presence of associated symptoms 3) what lesions and patients have a propensity to undergo this phenomenon and 4) the natural history of perilesional edema. A prospective study of 110 patients with only calcified granulomas and a history of seizures or severe headache has been completed. 50% of those who developed seizures had perilesional edema compare to 8.7% of asymptomatic matched controls. Therefore perilesional edema is common. The unusual and distinct nature of perilesional edema indicates a specific pathophysiology that may be amendable to unique interventions and treatments. ? ? A new treatment protocol for neurocysticercosis began enrolling patients in Lima, Peru. The purpose of the protocol is to determine if enhanced dosing of corticosteroids for one month with a two week taper decreases seizure frequency compared to 10 days of corticosteroids in albendazole treated patients with intraparenchymal cysticercosis without an unacceptable increase in side effects or a decrease in treatment efficacy. Much of the pathology and subsequently symptoms caused by cysticercosis are due to the host's immune response to the parasite that causes inflammation, seizures or focal neurological deficits. This leads to cyst degeneration, granuloma formation and/or calcification. The cysticidal agents, albendazole and praziquantel, initiate a similar process and until recently it was unclear if clinical benefit occurred with treatment. A recent double blinded randomized treatment sudy showed a clear benefit of treatment compared to no treatment . Although an overall decrease in generalized seizures was found after treatment with a standard regimen of albendazole and 6 mg dexamethasone/day for 10 days, a relative increase in seizures in the first month compared to later time periods suggested that inflammation was inadequately suppressed. Exactly what is the best way to suppress treatment-induced inflammation has not been studied and therefore is not known. The current protocol is an open label controlled study comparing the previous dexamethasone dosing of 10 days of 6 mg/day of dexamethasone with an enhanced dosing of 4 weeks of 8 mg/day with a 2 week taper. Albendazole dosing of both groups is identical. The primary end point is the number of seizures at specific time periods over the subsequent year, the number and severity of side effects and cure rates at 1 year.? ? Collaborative studies with Dr. Mahanty have been started to study the immune responses to cestodes that occur during the natural course of disease and also after treatment with the cysticidal agents albendazole and praziquantel. In cysticercosis the treatment of viable cysts many times initiates a vigorous immune response that appears similar if not identical to the type of inflammation found during the course of the natural infection. Seizures and other symptoms are common during treatment. Consequently, the problem in treatment is how to minimize symptoms and long-term damage due to treatment without preventing or inhibiting evolution to a relatively less destructive and less symptomatic granuloma. This question cannot be readily studied in humans. Therefore, studies using the cestode T. crassiceps infection in rats and mice have been initiated to answer this and other questions. A rat intracerebral model of T. crassciceps has been developed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000846-10
Application #
7732544
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
10
Fiscal Year
2008
Total Cost
$398,389
Indirect Cost
City
State
Country
United States
Zip Code
Carabin, H; Krecek, R C; Cowan, L D et al. (2006) Estimation of the cost of Taenia solium cysticercosis in Eastern Cape Province, South Africa. Trop Med Int Health 11:906-16
Nash, T E; Singh, G; White, A C et al. (2006) Treatment of neurocysticercosis: current status and future research needs. Neurology 67:1120-7
Garcia, Hector H; Del Brutto, Oscar H; Nash, Theodore E et al. (2005) New concepts in the diagnosis and management of neurocysticercosis (Taenia solium). Am J Trop Med Hyg 72:3-9
Nash, T E; Del Brutto, O H; Butman, J A et al. (2004) Calcific neurocysticercosis and epileptogenesis. Neurology 62:1934-8
Nash, Theodore E (2003) Human case management and treatment of cysticercosis. Acta Trop 87:61-9
Keiser, Paul B; Nash, Theodore E (2003) Prolonged perilesional edema after treatment of parenchymal neurocysticercosis: methotrexate as a corticosteroid-sparing agent. Clin Infect Dis 36:e122-6
Nash, T E; Pretell, J; Garcia, H H (2001) Calcified cysticerci provoke perilesional edema and seizures. Clin Infect Dis 33:1649-53
Del Brutto, O H; Rajshekhar, V; White Jr, A C et al. (2001) Proposed diagnostic criteria for neurocysticercosis. Neurology 57:177-83