Abstract

This is a natural history study of the gastrointestinal disease that affects a subset of CVID patients. Subjects with documented weight loss or diarrhea will be compared with CVID patients without gastrointestinal symptoms; subjects will have upper and lower endoscopy to evaluate histology and obtain specimens for LPMC purification; LPMC and PBMC will be immunophenotyped and tested for cytokine secretion; intestinal absorption will be measured; spleen size will be determined. We plan to recruit up to 10 subjects in the next year. The goal is to understand the T cell abnormality contributing to the idiopathic inflammatory bowel disease that can afflict these patients. Specific patterns of cytokine abnormalities should suggest specific therapies to test in this condition.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI000903-01
Application #
6674075
Study Section
(LCI)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2002
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Reinisch, Walter; Knobler, Robert; Rutgeerts, Paul J et al. (2013) Extracorporeal photopheresis (ECP) in patients with steroid-dependent Crohn's disease: an open-label, multicenter, prospective trial. Inflamm Bowel Dis 19:293-300
Yao, Michael D; von Rosenvinge, Erik C; Groden, Catherine et al. (2009) Multiple endoscopic biopsies in research subjects: safety results from a National Institutes of Health series. Gastrointest Endosc 69:906-10
von Rosenvinge, Erik C; Gopal, Lakshmi D; Heller, Theo et al. (2009) Rectal fistulae resulting from treatment with sorafenib and bevacizumab. Gastrointest Endosc :
Strober, Warren; Fuss, Ivan; Mannon, Peter (2007) The fundamental basis of inflammatory bowel disease. J Clin Invest 117:514-21
Foroughi, Shabnam; Foster, Barbara; Kim, Nayoung et al. (2007) Anti-IgE treatment of eosinophil-associated gastrointestinal disorders. J Allergy Clin Immunol 120:594-601
Mannon, Peter (2007) GAIN for loss: adalimumab for infliximab-refractory Crohn disease. Ann Intern Med 146:888-90
Mannon, Peter J; Fuss, Ivan J; Dill, Susie et al. (2006) Excess IL-12 but not IL-23 accompanies the inflammatory bowel disease associated with common variable immunodeficiency. Gastroenterology 131:748-56
Fuss, Ivan J; Becker, Christoph; Yang, Zhiqiong et al. (2006) Both IL-12p70 and IL-23 are synthesized during active Crohn's disease and are down-regulated by treatment with anti-IL-12 p40 monoclonal antibody. Inflamm Bowel Dis 12:9-15
Hussain, Nadeem; Quezado, Martha; Huizing, Marjan et al. (2006) Intestinal disease in Hermansky-Pudlak syndrome: occurrence of colitis and relation to genotype. Clin Gastroenterol Hepatol 4:73-80
Mannon, Peter J; Fuss, Ivan J; Mayer, Lloyd et al. (2004) Anti-interleukin-12 antibody for active Crohn's disease. N Engl J Med 351:2069-79

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