Abstract

This project focuses on basic cellular transformation events as related to HTLV-I. For this purpose, we study cellular genetic integrity, cell cycle progression and the checkpoints within a cell that guards normal cellular division. Some notable scientific advances from our research program in 2006-2007 include: 1) The discovery of a Tax-binding protein that serves to recruit a de-ubiquitinase that negatively regulates NF-kB signaling; 2) the characterization of the co-operativity between the spindle assembly checkpoint and the p53 checkpoint for tumorigenesis in mice; and 3) the delineation of the requirement of spindle assembly checkpoint protein for the localization of Plk-1 to kinetochores during mitosis and its implication for cellular transformation.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI001023-02
Application #
7732673
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2008
Total Cost
$876,847
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Peloponese Jr, Jean-Marie; Yasunaga, Junichiro; Kinjo, Takao et al. (2009) Peptidylproline cis-trans-isomerase Pin1 interacts with human T-cell leukemia virus type 1 tax and modulates its activation of NF-kappaB. J Virol 83:3238-48
Iwanaga, Yoichi; Chi, Ya-Hui; Miyazato, Akiko et al. (2007) Heterozygous deletion of mitotic arrest-deficient protein 1 (MAD1) increases the incidence of tumors in mice. Cancer Res 67:160-6
Chi, Ya-Hui; Jeang, Kuan-Teh (2007) Aneuploidy and cancer. J Cell Biochem 102:531-8
Matsuoka, Masao; Watanabe, Toshiki; Kannagi, Mari et al. (2007) Meeting report on the 13th International Conference on Human Retrovirology: human T-cell leukemia virus research 30 years after adult T-cell leukemia. Cancer Res 67:10638-41
Chi, Ya-Hui; Haller, Kerstin; Peloponese Jr, Jean-Marie et al. (2007) Histone acetyltransferase hALP and nuclear membrane protein hsSUN1 function in de-condensation of mitotic chromosomes. J Biol Chem 282:27447-58
Matsuoka, Masao; Jeang, Kuan-Teh (2007) Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation. Nat Rev Cancer 7:270-80
Chin, King-Tung; Chun, Abel C S; Ching, Yick-Pang et al. (2007) Human T-cell leukemia virus oncoprotein tax represses nuclear receptor-dependent transcription by targeting coactivator TAX1BP1. Cancer Res 67:1072-81
Sheleg, Sergey V; Peloponese, Jean-Marie; Chi, Ya-Hui et al. (2007) Evidence for cooperative transforming activity of the human pituitary tumor transforming gene and human T-cell leukemia virus type 1 Tax. J Virol 81:7894-901
Peloponese Jr, Jean-Marie; Kinjo, Takao; Jeang, Kuan-Teh (2007) Human T-cell leukemia virus type 1 Tax and cellular transformation. Int J Hematol 86:101-6
Osaki, Mitsuhiko; Inoue, Toshiaki; Yamaguchi, Shigeyuki et al. (2007) MAD1 (mitotic arrest deficiency 1) is a candidate for a tumor suppressor gene in human stomach. Virchows Arch 451:771-9

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