Abstract

A vaccine against HIV would provide a simple, low-cost means of controlling the spread of AIDS worldwide, particularly in the developing world where other treatments are unavailable. This research study aims to improve immunogenicity of HIV vaccines by selective mutation of HIV proteins and development of effective adjuvants. Promising candidates are being tested in both animal studies and human clinical trials.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005002-02
Application #
6822133
Study Section
(VIC)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2003
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Nabel, Gary J (2013) Designing tomorrow's vaccines. N Engl J Med 368:551-60
Wang, Lingshu; Cheng, Cheng; Ko, Sung-Youl et al. (2009) Delivery of human immunodeficiency virus vaccine vectors to the intestine induces enhanced mucosal cellular immunity. J Virol 83:7166-75
Shu, Yuuei; Winfrey, Sarah; Yang, Zhi-Yong et al. (2007) Efficient protein boosting after plasmid DNA or recombinant adenovirus immunization with HIV-1 vaccine constructs. Vaccine 25:1398-408
Catanzaro, Andrew T; Roederer, Mario; Koup, Richard A et al. (2007) Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25:4085-92
Tavel, Jorge A; Martin, Julie E; Kelly, Grace G et al. (2007) Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. J Acquir Immune Defic Syndr 44:601-5
Letvin, Norman L; Mascola, John R; Sun, Yue et al. (2006) Preserved CD4+ central memory T cells and survival in vaccinated SIV-challenged monkeys. Science 312:1530-3
Sun, Yue; Schmitz, Jorn E; Buzby, Adam P et al. (2006) Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge. J Virol 80:10950-6
Mattapallil, Joseph J; Douek, Daniel C; Buckler-White, Alicia et al. (2006) Vaccination preserves CD4 memory T cells during acute simian immunodeficiency virus challenge. J Exp Med 203:1533-41
Sheets, Rebecca L; Stein, Judith; Manetz, T Scott et al. (2006) Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts. Toxicol Sci 91:610-9
Graham, Barney S; Koup, Richard A; Roederer, Mario et al. (2006) Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J Infect Dis 194:1650-60

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