Abstract

A vaccine against Ebola virus would be highly significant in preventing outbreaks which are both naturally occurring or the result of bioterrorist activity. Modifications to previously developed Ebola vaccines were made during the past year to improve expression and immunogenicity.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005004-04
Application #
7174909
Study Section
(VIC)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Parkin, Neil; de Mendoza, Carmen; Schuurman, Rob et al. (2012) Evaluation of in-house genotyping assay performance using dried blood spot specimens in the Global World Health Organization laboratory network. Clin Infect Dis 54 Suppl 4:S273-9
Shanks, John; Burtnick, Mary N; Brett, Paul J et al. (2009) Burkholderia mallei tssM encodes a putative deubiquitinase that is secreted and expressed inside infected RAW 264.7 murine macrophages. Infect Immun 77:1636-48
Caliendo, Angela M; Ingersoll, Jessica; Fox-Canale, Andrea M et al. (2007) Evaluation of real-time PCR laboratory-developed tests using analyte-specific reagents for cytomegalovirus quantification. J Clin Microbiol 45:1723-7
Sullivan, Nancy J; Geisbert, Thomas W; Geisbert, Joan B et al. (2006) Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. PLoS Med 3:e177
Yu, Jae-Sung; Liao, Hua-Xin; Gerdon, Aren E et al. (2006) Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor. J Virol Methods 137:219-28
Sheets, Rebecca L; Stein, Judith; Manetz, T Scott et al. (2006) Biodistribution of DNA plasmid vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile virus is similar, without integration, despite differing plasmid backbones or gene inserts. Toxicol Sci 91:610-9
Sullivan, Nancy J; Peterson, Mary; Yang, Zhi-yong et al. (2005) Ebola virus glycoprotein toxicity is mediated by a dynamin-dependent protein-trafficking pathway. J Virol 79:547-53
Sullivan, Nancy J; Geisbert, Thomas W; Geisbert, Joan B et al. (2003) Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates. Nature 424:681-4
Sullivan, Nancy; Yang, Zhi-Yong; Nabel, Gary J (2003) Ebola virus pathogenesis: implications for vaccines and therapies. J Virol 77:9733-7
Nabel, Gary J (2003) Vaccine for AIDS and Ebola virus infection. Virus Res 92:213-7

Showing the most recent 10 out of 11 publications