T Cell Immune Responses To HIV And Other Pathogens

Koup, Richard A.

Abstract

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI005015-06
• Application #: 7592386
• Support Year: 6
• Fiscal Year: 2007
• Total Cost: $1,213,840

Institution

• Name: National Institute of Allergy and Infectious Diseases
• Country: United States

Publications

Geldmacher, Christof; Metzler, Ian S; Tovanabutra, Sodsai et al. (2009) Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response. Blood 114:1553-62

Petrovas, Constantinos; Price, David A; Mattapallil, Joseph et al. (2007) SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110:928-36

Precopio, Melissa L; Betts, Michael R; Parrino, Janie et al. (2007) Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med 204:1405-16

Lore, Karin; Adams, William C; Havenga, Menzo J E et al. (2007) Myeloid and plasmacytoid dendritic cells are susceptible to recombinant adenovirus vectors and stimulate polyfunctional memory T cell responses. J Immunol 179:1721-9

Yang, Litao; Peng, Hui; Zhu, Zhaoling et al. (2007) Persistent memory CD4+ and CD8+ T-cell responses in recovered severe acute respiratory syndrome (SARS) patients to SARS coronavirus M antigen. J Gen Virol 88:2740-8

Peng, Hui; Yang, Li-tao; Wang, Ling-yun et al. (2006) Long-lived memory T lymphocyte responses against SARS coronavirus nucleocapsid protein in SARS-recovered patients. Virology 351:466-75

Wille-Reece, Ulrike; Flynn, Barbara J; Lore, Karin et al. (2006) Toll-like receptor agonists influence the magnitude and quality of memory T cell responses after prime-boost immunization in nonhuman primates. J Exp Med 203:1249-58

Perfetto, Stephen P; Chattopadhyay, Pratip K; Lamoreaux, Laurie et al. (2006) Amine reactive dyes: an effective tool to discriminate live and dead cells in polychromatic flow cytometry. J Immunol Methods 313:199-208

Sullivan, Nancy J; Geisbert, Thomas W; Geisbert, Joan B et al. (2006) Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs. PLoS Med 3:e177

Peng, Hui; Yang, Li-tao; Li, Jian et al. (2006) Human memory T cell responses to SARS-CoV E protein. Microbes Infect 8:2424-31