CD4+ T cells can be segregated into distinct subsets based on their pattern of cytokine production. CD4+ T cells that secrete IFN-g are termed Th1 cells while cells that secrete IL-4, IL-5 and IL-13 are termed Th2 cells. While Th1 cells are essential in mediating protection against a variety of intracellular infections they also are mediate pro-inflammatory responses associated with a variety of autoimmune diseases. Th2 cells have a role in counter-regulating Th1 responses and are associated with allergic and asthmatic disease. These studies examine the factors, which regulate how T helper responses are sustained in vivo. Recent work explores the mechanism by which CD4+/IFN-g effector cells die in vivo.
| Foulds, Kathryn E; Rotte, Masashi J; Paley, Michael A et al. (2008) IFN-gamma mediates the death of Th1 cells in a paracrine manner. J Immunol 180:842-9 |
| Seder, Robert A; Darrah, Patricia A; Roederer, Mario (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8:247-58 |
| Darrah, Patricia A; Patel, Dipti T; De Luca, Paula M et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13:843-50 |
| Foulds, Kathryn E; Rotte, Masashi J; Seder, Robert A (2006) IL-10 is required for optimal CD8 T cell memory following Listeria monocytogenes infection. J Immunol 177:2565-74 |
| Foulds, Kathryn E; Wu, Chang-you; Seder, Robert A (2006) Th1 memory: implications for vaccine development. Immunol Rev 211:58-66 |
| Pulendran, Bali; Seder, Robert A (2005) Host-pathogen interactions in the 21st century. Curr Opin Immunol 17:335-7 |
| Seder, Robert A; Sacks, David L (2004) Memory may not need reminding. Nat Med 10:1045-7 |
