Functional And Phenotypic Characterization Of T Cells In Man

Roederer, Mario

Abstract

The immune system in man is extremely complex, comprised of dozens of functionally-unique cell subsets. Each of these subsets may have a special role in the protection from viruses or other challenges to the immune system; only now are we beginning to recognize the extent of this heterogeneity and correlate the presence and functional state of these cells with clinical status of subjects. We have focused on four main topics within this broad subject: The expression of cytotoxic effector molecules; the expression profile of chemokine receptors; the functional evaluation of cytolytic T cells; and the detailed cytokine profile of antigen-specific T cells.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI005021-07
• Application #: 7732744
• Support Year: 7
• Fiscal Year: 2008
• Total Cost: $964,975

Institution

• Name: National Institute of Allergy and Infectious Diseases
• Country: United States

Publications

Duvall, Melody G; Precopio, Melissa L; Ambrozak, David A et al. (2008) Polyfunctional T cell responses are a hallmark of HIV-2 infection. Eur J Immunol 38:350-63

Terabe, Masaki; Tagaya, Yutaka; Zhu, Qing et al. (2008) IL-15 expands unconventional CD8alphaalphaNK1.1+ T cells but not Valpha14Jalpha18+ NKT cells. J Immunol 180:7276-86

Seder, Robert A; Darrah, Patricia A; Roederer, Mario (2008) T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol 8:247-58

Parrino, Janie; McCurdy, Lewis H; Larkin, Brenda D et al. (2007) Safety, immunogenicity and efficacy of modified vaccinia Ankara (MVA) against Dryvax challenge in vaccinia-naive and vaccinia-immune individuals. Vaccine 25:1513-25

Petrovas, Constantinos; Price, David A; Mattapallil, Joseph et al. (2007) SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection. Blood 110:928-36

Precopio, Melissa L; Betts, Michael R; Parrino, Janie et al. (2007) Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8(+) T cell responses. J Exp Med 204:1405-16

Catanzaro, Andrew T; Roederer, Mario; Koup, Richard A et al. (2007) Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25:4085-92

Beveridge, Natalie E R; Price, David A; Casazza, Joseph P et al. (2007) Immunisation with BCG and recombinant MVA85A induces long-lasting, polyfunctional Mycobacterium tuberculosis-specific CD4+ memory T lymphocyte populations. Eur J Immunol 37:3089-100

Darrah, Patricia A; Patel, Dipti T; De Luca, Paula M et al. (2007) Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major. Nat Med 13:843-50

Li Pira, Giuseppina; Kern, Florian; Gratama, Jan et al. (2007) Measurement of antigen specific immune responses: 2006 update. Cytometry B Clin Cytom 72:77-85