T Cell Immune Responses To HIV And Other Pathogens

Douek, Daniel Cesar

Abstract

We have yet to fully define the immune responses associated with immunologic control of HIV replication. To develop an effective vaccine, we need to better understand the responses that may be controlling HIV, and why these defenses might fail. This study examines the T cell immune responses to HIV in naturally-infected subjects. It compares these responses with those generated against other viruses and non-viral pathogens in order to determine mechanisms of success or failure of an immune response.

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute of Allergy and Infectious Diseases (NIAID)
• Type: Intramural Research (Z01)
• Project #: 1Z01AI005033-06
• Application #: 7592402
• Support Year: 6
• Fiscal Year: 2007
• Total Cost: $339,289

Institution

• Name: National Institute of Allergy and Infectious Diseases
• Country: United States

Publications

Almeida, Jorge R; Sauce, Delphine; Price, David A et al. (2009) Antigen sensitivity is a major determinant of CD8+ T-cell polyfunctionality and HIV-suppressive activity. Blood 113:6351-60

Gordon, Shari N; Klatt, Nichole R; Bosinger, Steven E et al. (2007) Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol 179:3026-34

van Bockel, David; Price, David A; Asher, Tedi E et al. (2007) Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood. J Immunol Methods 326:127-38

Chattopadhyay, Pratip K; Douek, Daniel C; Gange, Stephen J et al. (2006) Longitudinal assessment of de novo T cell production in relation to HIV-associated T cell homeostasis failure. AIDS Res Hum Retroviruses 22:501-7

Duvall, Melody G; Jaye, Assan; Dong, Tao et al. (2006) Maintenance of HIV-specific CD4+ T cell help distinguishes HIV-2 from HIV-1 infection. J Immunol 176:6973-81

Petrovas, Constantinos; Casazza, Joseph P; Brenchley, Jason M et al. (2006) PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J Exp Med 203:2281-92

Brenchley, Jason M; Ruff, Laura E; Casazza, Joseph P et al. (2006) Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J Virol 80:6801-9

Casazza, Joseph P; Betts, Michael R; Price, David A et al. (2006) Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. J Exp Med 203:2865-77

Wooldridge, Linda; van den Berg, Hugo A; Glick, Meir et al. (2005) Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem 280:27491-501

Betts, Michael R; Exley, Barbara; Price, David A et al. (2005) Characterization of functional and phenotypic changes in anti-Gag vaccine-induced T cell responses and their role in protection after HIV-1 infection. Proc Natl Acad Sci U S A 102:4512-7