Abstract

HIV is known to primarily replicate in activated CD4+ T cells. In vitro studies have assessed the ability of HIV to replicate in multiple subsets of CD4+ T cells, and have identified several potential sources of T cells that are subject to infection by HIV. However, it remains unclear which CD4+ T cells are most frequently infected in vivo, and the impact of infection of these various subsets. This study seeks to define the subsets of CD4+ T cells that are naturally infected in patients, the anatomical sites of those infected cells and the impact upon HIV- and pathogen-specific immunity and the latent reservoir of HIV.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005034-07
Application #
7732753
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2008
Total Cost
$364,590
Indirect Cost

  Institution

Name
National Institute of Allergy and Infectious Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Gordon, Shari N; Klatt, Nichole R; Bosinger, Steven E et al. (2007) Severe depletion of mucosal CD4+ T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol 179:3026-34
Hryniewicz, Anna; Price, David A; Moniuszko, Marcin et al. (2007) Interleukin-15 but not interleukin-7 abrogates vaccine-induced decrease in virus level in simian immunodeficiency virus mac251-infected macaques. J Immunol 178:3492-504
Brenchley, Jason M; Price, David A; Douek, Daniel C (2006) HIV disease: fallout from a mucosal catastrophe? Nat Immunol 7:235-9
Brenchley, Jason M; Ruff, Laura E; Casazza, Joseph P et al. (2006) Preferential infection shortens the life span of human immunodeficiency virus-specific CD4+ T cells in vivo. J Virol 80:6801-9
Brenchley, Jason M; Price, David A; Schacker, Timothy W et al. (2006) Microbial translocation is a cause of systemic immune activation in chronic HIV infection. Nat Med 12:1365-71
Song, Kaimei; Rabin, Ronald L; Hill, Brenna J et al. (2005) Characterization of subsets of CD4+ memory T cells reveals early branched pathways of T cell differentiation in humans. Proc Natl Acad Sci U S A 102:7916-21
Takase, Hiroshi; Yu, Cheng-Rong; Mahdi, Rashid M et al. (2005) Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals. Int Immunol 17:1131-40
Mattapallil, Joseph J; Douek, Daniel C; Hill, Brenna et al. (2005) Massive infection and loss of memory CD4+ T cells in multiple tissues during acute SIV infection. Nature 434:1093-7
Fujiwara, Hiroshi; Melenhorst, J Joseph; El Ouriaghli, Frank et al. (2005) In vitro induction of myeloid leukemia-specific CD4 and CD8 T cells by CD40 ligand-activated B cells gene modified to express primary granule proteins. Clin Cancer Res 11:4495-503
Brenchley, Jason M; Schacker, Timothy W; Ruff, Laura E et al. (2004) CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 200:749-59

Showing the most recent 10 out of 12 publications