Abstract

Healthy, HIV-negative subjects are being recruited and screened for investigational preventive HIV vaccine clinical trials. This will continue in the next year. The results of the screening evaluations are used to determine if the subject meets eligibility requirements for participation in VRC Phase I trials of HIV preventive vaccines. Educational materials on vaccines are reviewed with and provided to subjects before enrollment into a study.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Intramural Research (Z01)
Project #
1Z01AI005035-03
Application #
6987335
Study Section
(CTC)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2004
Total Cost
Indirect Cost

  Institution

Name
Niaid Extramural Activities
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Koup, Richard A; Lamoreaux, Laurie; Zarkowsky, David et al. (2009) Replication-defective adenovirus vectors with multiple deletions do not induce measurable vector-specific T cells in human trials. J Virol 83:6318-22
Catanzaro, Andrew T; Roederer, Mario; Koup, Richard A et al. (2007) Phase I clinical evaluation of a six-plasmid multiclade HIV-1 DNA candidate vaccine. Vaccine 25:4085-92
Tavel, Jorge A; Martin, Julie E; Kelly, Grace G et al. (2007) Safety and immunogenicity of a Gag-Pol candidate HIV-1 DNA vaccine administered by a needle-free device in HIV-1-seronegative subjects. J Acquir Immune Defic Syndr 44:601-5
Catanzaro, Andrew T; Koup, Richard A; Roederer, Mario et al. (2006) Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 candidate vaccine delivered by a replication-defective recombinant adenovirus vector. J Infect Dis 194:1638-49
Graham, Barney S; Koup, Richard A; Roederer, Mario et al. (2006) Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J Infect Dis 194:1650-60
Khurana, Surender; Needham, James; Mathieson, Bonnie et al. (2006) Human immunodeficiency virus (HIV) vaccine trials: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies. J Virol 80:2092-9
Graham, Barney S; Mascola, John R (2005) Lessons from failure--preparing for future HIV-1 vaccine efficacy trials. J Infect Dis 191:647-9