We are studying specific immune responses to HIV infection in order to characterize protective responses which can prevent new infection in uninfected individuals, as well as define those responses which lead to successful control of viral replication in persons already infected with HIV. Because of the lack of an adequate animal model it is necessary to utilize human peripheral blood cells. We wish to define the specific human immune responses to HIV infection using human peripheral blood mononuclear cells as a model.
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| Khurana, Surender; Needham, James; Mathieson, Bonnie et al. (2006) Human immunodeficiency virus (HIV) vaccine trials: a novel assay for differential diagnosis of HIV infections in the face of vaccine-generated antibodies. J Virol 80:2092-9 |
