The goal of this study is the development of broad-spectrum antiviral agents. Synthetic chimeric proteins were created, which were composed of a targeting motif and a virus inactivating motif. The targeting motif has the ability to recognize and bind to viral envelope and the inactivating motif of the chimeric proteins cause viruses to lose their infectivity.
Kim, Jae-Ouk; Chakrabarti, Bimal K; Guha-Niyogi, Anuradha et al. (2007) Lysis of human immunodeficiency virus type 1 by a specific secreted human phospholipase A2. J Virol 81:1444-50 |