New statistical methods for analysis of the genetic component of complex familial diseases are needed in order to determine the relative contribution of environment and hereditary to a variety of traits, and to elucidate the specifics of these determinants. We have been focusing of the problem of genetic linkage studies in complex disorders (e.g. arthritis, other autoimmune diseases, mitochondrial diseases) when certain usual conditions of analysis are not met (e.g. known mendelian model, large sample size, non-normally-distributed quantitative trait measurements).

Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1992
Total Cost
Indirect Cost
Name
National Institute of Arthritis and Musculoskeletal and Skin Diseases
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Kovach, M J; Lin, J P; Boyadjiev, S et al. (1999) A unique point mutation in the PMP22 gene is associated with Charcot-Marie-Tooth disease and deafness. Am J Hum Genet 64:1580-93