The ATP-binding cassette (ABC) gene family encodes a diverse group of transporter proteins that pump a wide variety of compounds across the membranes of cells and tissues. Several human ABC transporters are overexpressed in tumor cells that are resistant to chemotherapy drugs. In addition, several ABC genes (CFTR, ABCC8, ABCD1) are mutated in inherited diseases. There are 48 human ABC genes, divided into 7 subfamilies. The recently described ABCA12 is expressed in the stomach and skin, and ABCA13 is expressed in the trachea, testes, and bone marrow. A cluster of ABCA3-like genes is present in the mouse genome and these genes are exclusively expressed in the testes where they may be involved in sperm maturation. We have documented that the ABCA3 gene is mutated in children with neonatal respiratory failure due to lung surfactant secretion. The ABCA3 gene is expressed in alveolal type II cells, where surfactants are produced. Ultramicroscopic analysis of lung tissue from these patients shows abnormal lamellar bodies in the alveolar cells. Further characterization of this gene should yield insights into surfactant secretion and lung function. The ABC genes were annotated in zebrafish which should be an excellent model for studying gene expression and function.
| Idelman, Gila; Jacobson, Eric M; Tuttle, Traci R et al. (2011) Lactogens and estrogens in breast cancer chemoresistance. Expert Rev Endocrinol Metab 6:411-422 |
| Borcherding, Dana C; Hugo, Eric R; Idelman, Gila et al. (2011) Dopamine receptors in human adipocytes: expression and functions. PLoS One 6:e25537 |
| LaPensee, Elizabeth W; LaPensee, Christopher R; Fox, Sejal et al. (2010) Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer Lett 290:167-73 |
| Jacobson, Eric M; Hugo, Eric R; Tuttle, Traci R et al. (2010) Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends Endocrinol Metab 21:691-8 |
| Lapensee, Elizabeth W; Tuttle, Traci R; Fox, Sejal R et al. (2009) Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Environ Health Perspect 117:175-80 |
| Dean, Michael (2009) ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia 14:3-9 |
| Ben-Jonathan, Nira; Hugo, Eric R; Brandebourg, Terry D (2009) Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome. Mol Cell Endocrinol 304:49-54 |
| Sturm, Armin; Cunningham, Phil; Dean, Michael (2009) The ABC transporter gene family of Daphnia pulex. BMC Genomics 10:170 |
| Li, Xing; Gold, Bert; O'hUigin, Colm et al. (2007) Unique features of TRIM5alpha among closely related human TRIM family members. Virology 360:419-33 |
| Saugstad, Ola D; Hansen, Thor Willy Ruud; Ronnestad, Arild et al. (2007) Novel mutations in the gene encoding ATP binding cassette protein member A3 (ABCA3) resulting in fatal neonatal lung disease. Acta Paediatr 96:185-90 |
Showing the most recent 10 out of 41 publications
