The ATP-binding cassette (ABC) gene family encodes a diverse group of transporter proteins that pump a wide variety of compounds across the membranes of cells and tissues. Several human ABC transporters are overexpressed in tumor cells that are resistant to chemotherapy drugs. In addition, several ABC genes (CFTR, ABCC8, ABCD1) are mutated in inherited diseases. There are 48 human ABC genes, divided into 7 subfamilies. The recently described ABCA12 is expressed in the stomach and skin, and ABCA13 is expressed in the trachea, testes, and bone marrow. A cluster of ABCA3-like genes is present in the mouse genome and these genes are exclusively expressed in the testes where they may be involved in sperm maturation. We have documented that the ABCA3 gene is mutated in children with neonatal respiratory failure due to lung surfactant secretion. The ABCA3 gene is expressed in alveolal type II cells, where surfactants are produced. Ultramicroscopic analysis of lung tissue from these patients shows abnormal lamellar bodies in the alveolar cells. Further characterization of this gene should yield insights into surfactant secretion and lung function. The ABC genes were annotated in zebrafish which should be an excellent model for studying gene expression and function.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC005725-11
Application #
6950131
Study Section
(LGD)
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2003
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Idelman, Gila; Jacobson, Eric M; Tuttle, Traci R et al. (2011) Lactogens and estrogens in breast cancer chemoresistance. Expert Rev Endocrinol Metab 6:411-422
Borcherding, Dana C; Hugo, Eric R; Idelman, Gila et al. (2011) Dopamine receptors in human adipocytes: expression and functions. PLoS One 6:e25537
LaPensee, Elizabeth W; LaPensee, Christopher R; Fox, Sejal et al. (2010) Bisphenol A and estradiol are equipotent in antagonizing cisplatin-induced cytotoxicity in breast cancer cells. Cancer Lett 290:167-73
Jacobson, Eric M; Hugo, Eric R; Tuttle, Traci R et al. (2010) Unexploited therapies in breast and prostate cancer: blockade of the prolactin receptor. Trends Endocrinol Metab 21:691-8
Lapensee, Elizabeth W; Tuttle, Traci R; Fox, Sejal R et al. (2009) Bisphenol A at low nanomolar doses confers chemoresistance in estrogen receptor-alpha-positive and -negative breast cancer cells. Environ Health Perspect 117:175-80
Dean, Michael (2009) ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia 14:3-9
Ben-Jonathan, Nira; Hugo, Eric R; Brandebourg, Terry D (2009) Effects of bisphenol A on adipokine release from human adipose tissue: Implications for the metabolic syndrome. Mol Cell Endocrinol 304:49-54
Sturm, Armin; Cunningham, Phil; Dean, Michael (2009) The ABC transporter gene family of Daphnia pulex. BMC Genomics 10:170
Henrich, Curtis J; Robey, Robert W; Bokesch, Heidi R et al. (2007) New inhibitors of ABCG2 identified by high-throughput screening. Mol Cancer Ther 6:3271-8
Lou, H; Dean, M (2007) Targeted therapy for cancer stem cells: the patched pathway and ABC transporters. Oncogene 26:1357-60

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