Focal segmental glomerulosclerosis (FSGS), a chronic renal disease, is associated with HIV-1, heroin use, and sickle cell anemia within the African-American (AA) population, but not generally in Caucasians. The increased prevalence of FSGS in AAs suggests a genetic component that may underlie predisposition to FSGS. We are currently establishing lymphoblastoid cell lines from three groups of patients for a genetic analysis using 300 microsatellite markers and specific candidate genes. The patient groups are: 1) 100 AAs with FSGS but without HIV infection, 2)100 AAs with FSGS and HIV infection, and 3) 200 HIV seropositive AA patients without evidence of clinical renal disease. Cell lines have been established for approximately 100 patients in categories 1 and 2. Patients in category 3 are being identified from the 1200 AAs with cell lines in the LGD repository.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010022-02
Application #
6161114
Study Section
Special Emphasis Panel (LGD)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1997
Total Cost
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Franceschini, Nora; North, Kari E; Kopp, Jeffrey B et al. (2006) NPHS2 gene, nephrotic syndrome and focal segmental glomerulosclerosis: a HuGE review. Genet Med 8:63-75
Kopp, Jeffrey B; Winkler, Cheryl (2003) HIV-associated nephropathy in African Americans. Kidney Int Suppl :S43-9