Genome-wide association analysis with a dense marker set, mapping by admixture linkage disequilibrium (MALD) with ancestry informative markers, and examination of candidate gene analysis each requires a high-throughput genotyping laboratory. Utilizing the core laboratory we have developed at the Laboratory of Genomic Diversity (LGD) has allowed determination and publication of a MALD map for disease gene discovery in African Americans. Our collaborators have now used that map and the MALD method for gene identification in prostate cancer and IL-6 levels along with gene localization in multiple sclerosis. Ongoing efforts in our laboratory are applying the MALD technology to HIV/AIDS, Hepatitis C virus (HCV), focal segmental glomerulosclerosis, and end-stage renal disease. The laboratory has also undertaken candidate gene analysis for HIV-1, HCV, HBV and cardiovascular disease complications of end-stage renal disease.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010270-11
Application #
7592639
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2007
Total Cost
$516,254
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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