Abstract

All genomes exist and function in the cell nucleus. Although we have made strides in decoding entire genomes, we only poorly understand how genomes function in intact cells. Our cell biological studies of genomes and the cell nucleus are aimed at uncovering fundamental concepts of genome organization and nuclear function in vivo and they are providing opportunities for applying these principles to human disease diagnosis, therapeutics and bioengineering. ?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010309-07
Application #
7291700
Study Section
(LRBG)
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
2005
Total Cost
Indirect Cost

  Institution

Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Pegoraro, Gianluca; Misteli, Tom (2009) The central role of chromatin maintenance in aging. Aging (Albany NY) 1:1017-22
Hager, Gordon L; McNally, James G; Misteli, Tom (2009) Transcription dynamics. Mol Cell 35:741-53
Mathas, Stephan; Kreher, Stephan; Meaburn, Karen J et al. (2009) Gene deregulation and spatial genome reorganization near breakpoints prior to formation of translocations in anaplastic large cell lymphoma. Proc Natl Acad Sci U S A 106:5831-6
Misteli, Tom (2009) Self-organization in the genome. Proc Natl Acad Sci U S A 106:6885-6
Mejat, Alexandre; Decostre, Valerie; Li, Juan et al. (2009) Lamin A/C-mediated neuromuscular junction defects in Emery-Dreifuss muscular dystrophy. J Cell Biol 184:31-44
Soutoglou, Evi; Dorn, Jonas F; Sengupta, Kundan et al. (2007) Positional stability of single double-strand breaks in mammalian cells. Nat Cell Biol 9:675-82
Trotman, Lloyd C; Wang, Xinjiang; Alimonti, Andrea et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell 128:141-56
Soutoglou, Evi; Misteli, Tom (2007) Mobility and immobility of chromatin in transcription and genome stability. Curr Opin Genet Dev 17:435-42
Meaburn, Karen J; Misteli, Tom; Soutoglou, Evi (2007) Spatial genome organization in the formation of chromosomal translocations. Semin Cancer Biol 17:80-90
Kruhlak, Michael; Crouch, Elizabeth E; Orlov, Marika et al. (2007) The ATM repair pathway inhibits RNA polymerase I transcription in response to chromosome breaks. Nature 447:730-4

Showing the most recent 10 out of 29 publications