The research within this Section concentrates on the utilization of the unique properties of the X-ray radiation generated at the synchrotron and in particular at very intense undulator beam lines of the Advanced Photon Source (APS) at the Argonne National Laboratory, where we are located. The two most important characteristics of synchrotron radiation are the high intensity of the X-ray beam and the tunability of the wavelength; both of these properties are utilized in the research investigations within the Section. In addition to conducting research investigations, the Section personnel provides technological and scientific support for NIH researchers collecting diffraction data at APS.

National Institute of Health (NIH)
Division of Basic Sciences - NCI (NCI)
Intramural Research (Z01)
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Mammalian Cell Lines Committee (MCL)
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Basic Sciences
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Jaskolski, Mariusz; Gilski, Miroslaw; Dauter, Zbigniew et al. (2007) Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? Acta Crystallogr D Biol Crystallogr 63:611-20
Meijers, Rob; Adolph, Hans-Werner; Dauter, Zbigniew et al. (2007) Structural evidence for a ligand coordination switch in liver alcohol dehydrogenase. Biochemistry 46:5446-54
Jedrzejczak, Robert; Dauter, Zbigniew; Dauter, Miroslawa et al. (2006) Structure of DraD invasin from uropathogenic Escherichia coli: a dimer with swapped beta-tails. Acta Crystallogr D Biol Crystallogr 62:157-64
Bielnicki, Jakub; Devedjiev, Yancho; Derewenda, Urszula et al. (2006) B. subtilis ykuD protein at 2.0 A resolution: insights into the structure and function of a novel, ubiquitous family of bacterial enzymes. Proteins 62:144-51
Sekar, K; Yogavel, M; Kanaujia, Shankar Prasad et al. (2006) Suggestive evidence for the involvement of the second calcium and surface loop in interfacial binding: monoclinic and trigonal crystal structures of a quadruple mutant of phospholipase A2. Acta Crystallogr D Biol Crystallogr 62:717-24
Liu, Yizhou; Cheney, Matthew D; Gaudet, Justin J et al. (2006) The tetramer structure of the Nervy homology two domain, NHR2, is critical for AML1/ETO's activity. Cancer Cell 9:249-60
Dauter, Zbigniew (2006) Estimation of anomalous signal in diffraction data. Acta Crystallogr D Biol Crystallogr 62:867-76
Sekar, K; Yogavel, M; Gayathri, D et al. (2006) Atomic resolution structure of the double mutant (K53,56M) of bovine pancreatic phospholipase A2. Acta Crystallogr Sect F Struct Biol Cryst Commun 62:1-5
Dauter, Zbigniew (2006) Current state and prospects of macromolecular crystallography. Acta Crystallogr D Biol Crystallogr 62:1-11
Serganov, Alexander; Keiper, Sonja; Malinina, Lucy et al. (2005) Structural basis for Diels-Alder ribozyme-catalyzed carbon-carbon bond formation. Nat Struct Mol Biol 12:218-24

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