Children with brain tumors are generally followed by imaging studies, such as MRI. Difficulty arises in trying to distinguish tumor regrowth from treatment-related edema, necrosis or radiation injury. Proton nuclear magnetic resonance (NMRS) imaging is a noninvasive method of detecting and measuring cellular metabolites in vivo. NMRS complements MRI by giving chemical information in conjunction with spatial information obtained by MRI. This study is being conducted to determine NMRS imaging patterns before, during and after chemotherapy in pediatric patients with brain tumors in an effort to identify and characterize specific patterns of metabolites related to tumor regrowth, response to therapy, edema or necrosis.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010584-02
Application #
7292863
Study Section
(NOB)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2005
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Steffen-Smith, Emilie A; Venzon, David J; Bent, Robyn S et al. (2012) Single- and multivoxel proton spectroscopy in pediatric patients with diffuse intrinsic pontine glioma. Int J Radiat Oncol Biol Phys 84:774-9