The study has accrued quickly and is ongoing. We are currently evaluating a dose of lenalidomide that is > 2x the typical adult dose and have not seen significant toxicity in our study population. We have observed at least seven (7) patients with long-term stable disease (> 6 months) which is significant in a Phase I study. There are plans and letters of intent to further develop this agent and test efficacy in a Phase II study within the Children's Oncology Group and in combination trials within NCI.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010585-04
Application #
7592780
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
2007
Total Cost
$137,257
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code