Another area, which we will focus on, is the monitoring of gene expression changes impacted by drugs. The choice and design of many chemotherapeutic agents currently used in cancer treatment has been traditionally empirical in nature. The molecular mechanisms of their actions are not well understood, and their mode of action is often indiscriminate targeting, both of tumor and normal cells. We will identify molecular signature of effect of drugs acting on neuroblastoma. We will screening series of novel drugs to predict how they work based on their gene expression signature.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010594-03
Application #
7338717
Study Section
(POB)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
2006
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code
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Alabran, Jennifer L; Cheuk, Adam; Liby, Karen et al. (2008) Human neuroblastoma cells rapidly enter cell cycle arrest and apoptosis following exposure to C-28 derivatives of the synthetic triterpenoid CDDO. Cancer Biol Ther 7:709-17
Wei, Jun S; Whiteford, Craig C; Cenacchi, Nicola et al. (2005) BBC3 mediates fenretinide-induced cell death in neuroblastoma. Oncogene 24:7976-83
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