My laboratory is also evaluating the utility of gene methylation in the early detection of upper GI cancer among subects in a high-risk region of China. This work is being conducted in a population-based screening cohort, the Cytology Sampling Study 2 (CSS2). The CSS2 was conducted to estimate the sensitivity of the newly designed esophageal cytology sampler for detecting squamous dysplasia and carcinoma (ESCC) in comparison with the standard balloon cytology sampling devise. Molecular markers are currently being evaluated in both cytology cells and serum to predict esophageal dysplasia/cancer to facilitate large-scale screening of high-risk populations. Gene methylation may be a good candidate marker for these studies.

Agency
National Institute of Health (NIH)
Institute
Division of Basic Sciences - NCI (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC010604-01
Application #
7064467
Study Section
(GB)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2004
Total Cost
Indirect Cost
Name
Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code