In this project we will transplant Nude/SCID mice with human bone marrow. Subsequently, we will transplant HLA matched various human cancers to variou sites. We will determine whether bone marrow derrived stem cells caarrying one reporter gene are migrating preferentially to areas of active cancers as in """"""""healing wound"""""""". Since both tumor cells and the stem cells will carry a different reporter gene, we will be able to determine whether fusion occured. If fusion occur to any clinical significance we will try to understand its mechanism, receptor and block it. We will also determine what makes normal bone marrow stem cells migrate into cancer and participate in carcinogenesis

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01BC011004-01
Application #
7733408
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2008
Total Cost
$118,703
Indirect Cost
Name
National Cancer Institute Division of Basic Sciences
Department
Type
DUNS #
City
State
Country
United States
Zip Code