We analyzed sera reactive by HTLV I ELISA to pedigree reagents for HTLV I lot release. Sera were identified as HTLV I reactive by the Stanford Blood Bank. Lymphocytes from the positive patients were then analyzed to determine whether the patient was infected with HTLV I or HTLV II. PCR u specific primer pairs was performed. In addition, specific primer pairs and probes to HTLV II tax gene region were developed and characterized. We identified about 10 sera that were characterized as HTLV II by PCR that will be used as a reference and lot release panel. Two sera that were HTLV II positive were from husband and wife and represents a case of sexual transmission of HTLV II.

Agency
National Institute of Health (NIH)
Institute
Food and Drug Administration (FDA)
Type
Intramural Research (Z01)
Project #
1Z01BG006053-01
Application #
3804865
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Center Biologics Evaluation Research Transfusion
Department
Type
DUNS #
City
State
Country
United States
Zip Code