We continued research on the molecular mechanism of meiotic recombination in the yeast Saccharomyces cerevisiae. We have focused on an initiating event in meiotic recombination, the formation of double-strand DNA breaks, with an aim towards determining the factors that control the level and position of these breaks, and isolating the enzyme(s) responsible for their formation. In addition we have analyzed several short regions of the yeast genome that contain sequences that stimulate both meiotic recombination and double-strand DNA breaks.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CB005268-04
Application #
3796445
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Division of Cancer Biology and Diagnosis
Department
Type
DUNS #
City
State
Country
United States
Zip Code