Patients with chronic granulomatous disease (CGD) frequently develop pulmonary infections. In many patients with CGD an accurate diagnosis is difficult to establish due to the scarcity of organisms in pathologic specimens. This study assesses, in a retrospective manner, all procedural as well as diagnostic data in patients with CGD and pulmonary disease. The study assesses the utility of sputum, bronchoscopy (lavage and transbronchial biopsy), CTT-guided transthoracic needle aspiration, and open lung biopsy in establishing either a definitive or presumptive pulmonary diagnosis. The goal is to establish a diagnostic algorithm for pulmonary procedures in patients with CGD based on relative invasiveness and diagnostic yield. Data are being collected from chart reviews for analysis from 65 patients over a 15-year period.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL000165-04
Application #
6289403
Study Section
Special Emphasis Panel (CCMB)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code