Human airway epithelial cells lining the conduction airways produce Clara Cell Secretory Protein (CCSP). This protein is an inhibitor of phospholipase A2 and has other immunomodulatory properties. A human airway bronchial epithelial cell line has been found to express mRNA for CCSP and to produce and secrete CCSP. CCSP secretion and levels of steady state CCSP mRNA were altered by treatment of these human airway epithelial cells with interferon-gamma in a time and dose dependent fashion. This project is completed. Two manuscripts have been published.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL000181-04
Application #
6289410
Study Section
Special Emphasis Panel (CCMB)
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code