We have studied a total of 25 patients with metastatic colon or appendiceal adenocarcinoma. All patients received I-131 B72.3 intraperitoneally. In addition selected patients were co-infused with a control antibody to determine the specificity of localization. In other cases the patients were co-injected with I-125 B72.3 intravenously to determine which was the better route. We have documented tumor specific uptake. We have also documented that there is preferential targeting of peritoneal implants by the intraperitoneal route compared to the intraperitoneal route. Most patients receiving intraperitoneal antibody developed human antimouse antibodies. No patients have been recruited in the last year.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL000603-07
Application #
3853071
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
7
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code