Despite sensitive radioimmunoassay test for HBsAg applied to all donor blood, some type B hepatitis continues to occur following transfusion. It has previously been suggested that HBsAg-negative individuals that have anti-core antibody may transmit the hepatitis B virus. The availability of a new sensitive radioimmunoassay for anti-core antibody allows this postulate to be tested in our prospectively followed open heart surgery patients. Current tests also allow for determinations of IgM versus IgG anti-core antibody and the clinical significance of these antibody subclasses will also be investigated. In addition, it has been suggested that there is a relationship between anti-core antibody in the donor and non-A, non-B hepatitis in the recipient. This relationship will be examined in our prespectively collected samples.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL002016-09
Application #
4691946
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code