In order to be able to optimally dose patients with cisplatin and minimize its systemic toxicity, we have evaluated a total of 4 patients who were administered 5 mg bolus of indocyamine green (ICG) along with 0.5 mg/ml ICG infusion at 3.5 mg/min into the internal carotid artery. Plasma ICG levels were quickly measured by using a spectrophotometric method in the first three and a relatively simple MPLC method (abs: 800 nm) in the last patient. ICG clearance as a function of jugular aspiration flow rate (range: 50-350 mg/min). Results in patient appear to show a linear correlation (r greater than 0.95) and support preclinical investigation in monkeys that correlated the flow rates with ICG clearance.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL005061-04
Application #
3939451
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code