Initial studies of the effect of surgical manipulation (i.e. parathyroid and thyroid surgery) on the effect of hormone (ACTH, B endorphin, cortisol, tissue CRH, vasopressin, oxytocin, catecholamine, angiotensin II, cyclic AMP) levels did not show significant alteration. Instead, anesthesia changes (with induction and reversal) had the most dramatic effects. In this study, the degree of surgical stress has been increased (i.e. laparotomy), the anesthetic has been kept relatively constant and the hormone levels have been measured. A significant change is expected.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL008019-02
Application #
3916498
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code