The goal of these studies is to understand the possible role of viral proteins in the induction of cellular cytotoxicity in human lung epithelial cells. Two proteins were identified which appear to track to mitochondria and to cause mitochondrial toxicity by ultrastructural analysis. One protein causes cytochrome C release into the cytoplasma and mitochondrial apoptosis. The other appears to cause mitochondrial autophagy. Studies are ongoing to define protein interactions and pathways by which these changes may occur.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL008095-01
Application #
7593095
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2007
Total Cost
$241,979
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code