This project investigates the interaction of factor VIII with other coagulation factors, particularly with factor IXa, activated protein C, calcium ions, and phospholipid in the quaternary complex formed by these factors. The importance of proteolytic activation of factor VIII prior to its participation in the complex will be assessed, and the nonfunctional factor VIII molecule present in patients with hemophilia A will be studied to determine whether it can participate in the quaternary complex. The importance of platelets and platelet membranes vs. phospholipid will be assessed.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010035-12
Application #
3837977
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
12
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code