The Jaffe reaction (creatinine and alkaline picrate) was studied to elucidate its spectral mechanism and to determine which functional groups on cefoxitin and cephalothin react with picrate. Suitable evidence was obtained to infer that of the carbonyl groups on cefoxitin or cephalothin, the lactam ring is responsible for the slow reaction and the acetamido group is responsible for the fast reaction. An autocatalytic reaction between picrate and carbohydrates was identified and studied.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010085-08
Application #
3874340
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code