Autoimmune (Idiopathic) Thrombocytopenic Purpura (ITP) is a disease caused by autoantibodies directed against platelets. The demonstration of specific antibodies has been difficult for a variety of reasons. In general, when the antibodies can be demonstrated, there is an inverse correlation with the platelet count. We have set up two assays, one screening assay and one specific assay for specific platelet glycoproteins, to aid in the diagnosis and progress of treatment for patients with ITP. We will utilize the tests particularly for follow- ing patients pre- and post-treatment in a pilot study with NHLBI in the treatment setting of T-cell-depleted auto-stem cell transplantation in patients with severe ITP. Sixteen patients have been studied. Preliminary data were presented at the national meeting of the American Society of Hematology in December, 1998.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010283-03
Application #
6289478
Study Section
Cognition and Perception Study Section (CP)
Project Start
Project End
Budget Start
Budget End
Support Year
3
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code