A project to evaluate the CD45 alternative isoform, B220, expression on lymphocytes has been initiated. This is being done in healthy subjects and patients with autoimmune lymphoproliferative syndrome (ALPS) as well as other patients with lymphocyte disorders. Preliminary data suggest that this isoform is expressed at different levels in certain lymphocyte disorders and may serve as a characteristic finding in subtypes of ALPS. In addition, it appears to distinguish a subset of memory B cells and also is expressed on ono-isotype switched B cells that do not have a memory phenotype.
| Bleesing, J J; Brown, M R; Dale, J K et al. (2001) TcR-alpha/beta(+) CD4(-)CD8(-) T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin Immunol 100:314-24 |
