Abstract

For several years we have been treating deep vein thrombosis with recombinant tissue plasminogen activator that is injected directly into the clots. We have now collected blood samples before and at several time points following the treatment to determine how long the drug has a systemic effect. We found that it only circulates in an active form for 1 - 2 hours after injection and then becomes inhibited by a rise in plasminogen activator inhibitor-1. This work has now been published.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL010338-02
Application #
7004838
Study Section
(DLM)
Project Start
Project End
Budget Start
Budget End
Support Year
2
Fiscal Year
2004
Total Cost
Indirect Cost

  Institution

Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code