We are studying the development of the upper aerodigestive tract which includes the oropharynx, larynx, pharynx, tongue and bronchial system in the fetus with ultrasound imaging. Pregnant women who receive care at the National Naval Medical Center are randomly selected at their regular ultrasound visits to participate in this study. The regular clinical ultrasound examination is videotaped for later analysis. Both power and color Doppler techniques are used to determine early oral pharyngeal behaviors, track amniotic fluid flow,and vascular sufficiency.Two-dimentional B-mode ultrasound images are obtained to track the growth pattern of the structures of the upper aerodigestive tract. Children who are at risk for developing abnormal feeding at birth will be carefully followed during the course of repeated studies and provided with intervention to facilitate feeding if required. We hope to develop clinical indicators that signal the possibility of aerodigestive dysfunction after birth. We have evaluated 66 fetuses(GA 15 weeks to 39 weeks) in women ages 19-42 and will continue until we have 100 normal appearing fetuses and 20 who appear to be at risk for developing delayed feeding patterns.

Agency
National Institute of Health (NIH)
Institute
Clinical Center (CLC)
Type
Intramural Research (Z01)
Project #
1Z01CL060054-01
Application #
6535701
Study Section
(RM)
Project Start
Project End
Budget Start
Budget End
Support Year
1
Fiscal Year
2001
Total Cost
Indirect Cost
Name
Clinical Center
Department
Type
DUNS #
City
State
Country
United States
Zip Code
Macedonia, Christian; Miller, Jeri L; Sonies, Barbara C (2002) Power Doppler imaging of the fetal upper aerodigestive tract using a 4-point standardized evaluation: preliminary report. J Ultrasound Med 21:869-78