Abstract

The overall goal of this project is to develop an understanding of the genetic as well as environmental influences that are involved in the etiology of human esophageal cancer. These studies are being conducted in North Central China where rates of esophageal cancer are highest in the world, and where extraordinary familial aggregation of the disease exists. A series of studies to evaluate the role of genetics in the etiology of esophageal cancer have been conducted, including studies of family history of esophageal cancer, familial aggregation, and segregation analyses of family pedigrees from high risk families. Future studies will search for esophageal cancer susceptibility genes through genomic searches of tumor/nontumor tissue and prospective followup of high risk families for linkage analysis. This study is being conducted collaboratively with scientists at the Chinese Academy of Medical Sciences, the National Center for Human Genome Research, and the Fox Chase Cancer Center.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CN000150-06
Application #
3752544
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Division of Cancer Prevention and Control
Department
Type
DUNS #
City
State
Country
United States
Zip Code

  Publications

Abnet, Christian C; Huppi, Konrad; Carrera, Ana et al. (2004) Control region mutations and the 'common deletion' are frequent in the mitochondrial DNA of patients with esophageal squamous cell carcinoma. BMC Cancer 4:30
Jin, Ping; Zhao, Yingdong; Ngalame, Yvonne et al. (2004) Selection and validation of endogenous reference genes using a high throughput approach. BMC Genomics 5:55
Hu, Nan; Flaig, Michael J; Su, Hua et al. (2004) Comprehensive characterization of annexin I alterations in esophageal squamous cell carcinoma. Clin Cancer Res 10:6013-22
Hu, Nan; Wang, Chaoyu; Su, Hua et al. (2004) High frequency of CDKN2A alterations in esophageal squamous cell carcinoma from a high-risk Chinese population. Genes Chromosomes Cancer 39:205-16
Hu, Nan; Wang, Chaoyu; Han, Xiao-You et al. (2004) Evaluation of BRCA2 in the genetic susceptibility of familial esophageal cancer. Oncogene 23:852-8
Lu, Ning; Hu, Nan; Li, Wen-Jun et al. (2003) Microsatellite alterations in esophageal dysplasia and squamous cell carcinoma from laser capture microdissected endoscopic biopsies. Cancer Lett 189:137-45
Hu, Nan; Goldstein, Alisa M; Albert, Paul S et al. (2003) Evidence for a familial esophageal cancer susceptibility gene on chromosome 13. Cancer Epidemiol Biomarkers Prev 12:1112-5
Su, Hua; Hu, Nan; Shih, Joanna et al. (2003) Gene expression analysis of esophageal squamous cell carcinoma reveals consistent molecular profiles related to a family history of upper gastrointestinal cancer. Cancer Res 63:3872-6
Huang, J; Hu, N; Goldstein, A M et al. (2000) High frequency allelic loss on chromosome 17p13.3-p11.1 in esophageal squamous cell carcinomas from a high incidence area in northern China. Carcinogenesis 21:2019-26
Paweletz, C P; Ornstein, D K; Roth, M J et al. (2000) Loss of annexin 1 correlates with early onset of tumorigenesis in esophageal and prostate carcinoma. Cancer Res 60:6293-7

Showing the most recent 10 out of 14 publications