Additional studies of the mechanisms by which """"""""Fenton"""""""" oxidation (i.e., oxidation effected by reactive intermediates formed in mixtures of hydrogen peroxide with ferrous ion) occurs have been conducted. Further evidence against a kinetically significant role for hydroxyl radical was obtained. The reactivity of the reactive iron-oxo intermediates with other organic substrates, including amino acids and nucleic acid constituents, was characterized. In addition, a series of unusual N- nitroso compounds formed by reacting various nucleophiles with nitric oxide is being investigated.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP004542-21
Application #
3774767
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
21
Fiscal Year
1993
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code