The purpose of this project is to demonstrate the effects of selected oncogenes in appropriate rodent hosts. In addition, the mechanisms of malignant transformation are analyzed by in vitro and in vivo correlations. Using Type C viral vectors, the oncogenes erbB-2, erbB-3, HGF and IL-4 are on test in nude athymic and euthymic mouse cohorts. In transplantation experiments (allografts and xenografts), comparisons in tumorigenicity between erbB-2 transfectants and cancers naturally expressing the oncogene have been done; similarities and differences have been determined. Other oncogenes tested in transplant experiments were HGF, erbB-3, INT4, v-abl, arg, PDGF, ect2 and Epstein-Barr virus (EBV) cDNA. Three new spontaneous human cancers (kidney carcinoma, lung carcinoma and ocular melanoma) have been transplanted and are being analyzed.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP004930-20
Application #
3853404
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
20
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code