The following results were reported: (1) Establishment and characterization of origin-defective SV4O genome immortalized adult human prostatic epithelial cells; (2) neoplastic transformation of SV4O T- antigen immortalized human keratinocyte (RHEK-1) line by two human herpesvirus (HHV)-6 DNA clones; (3) demonstration of altered epidermal growth factor signal transduction in activated Ha-a transformed human keratinocytes; (4) demonstration of the use of RHEK-1 immortalized human keratinocytes for detection of induced mutation at the hypoxanthine- guanine phosphoribosyltransferase locus; (5) demonstration of the role of chromosome 5 in immortalization and tumorigenesis of human keratinocytes; (6) development of an in vitro model of human corneal epithelium for ocular studies; and (7) immortalization of mouse bone marrow-derived mast cells with Ad12-SV4O virus.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP005060-16
Application #
3752615
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Division of Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code