We have cloned and analyzed cDNA sequences derived from a family of genes which encode the classical transplantation antigens. Our findings have led to a better understanding of the structure and function of these cell surface antigens, particularly with regard to the regulation of their expression in both normal and cancer cells. We have studied the expression and function of the human interleukin-2 receptor. Our findings suggest the existence of a secreted interleukin-2 receptor which can bind interleukin-2 efficiently, and may function to regulate the interaction between interleukin-2 and its cell surface receptor. By using DNA- mediated gene transfer, we have demonstrated that the interleukin-2 receptor can function effectively in nonlymphoid cells.

Agency
National Institute of Health (NIH)
Institute
Division of Cancer Epidemiology And Genetics (NCI)
Type
Intramural Research (Z01)
Project #
1Z01CP005220-08
Application #
3939644
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Cancer Epidemiology and Genetics
Department
Type
DUNS #
City
State
Country
United States
Zip Code